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Optical quality of the transplanted cornea after Descemet's membrane endothelial keratoplasty

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Session Details

Session Title: Cornea Surgical I

Session Date/Time: Monday 15/09/2014 | 08:00-10:30

Paper Time: 09:14

Venue: Boulevard B

First Author: : J.Parker USA

Co Author(s): :    K. van Dijk   K. Droutsas   J. Hou   S. Sangsari   V. Liarakos   G. Melles

Abstract Details


To evaluate corneal higher order aberrations (HOAs) and densitometry before and after Descemet membrane endothelial keratoplasty (DMEK) and their correlation with visual outcome.


Netherlands Institute for Innovative Ocular Surgery / Tertiary referral center.


In a total of 118 consecutive eyes of 118 patients who underwent uneventful DMEK for Fuchs endothelial dystrophy (FED) at a tertiary referral center, best spectacle corrected visual acuity (BSCVA), corneal HOAs and densitometry were retrospectively evaluated, preoperatively and at 6 months postoperatively. Outcome data were compared to an age-matched control group with uncomplicated eyes (n=27).


Compared to the control group, DMEK eyes showed higher values of anterior and posterior HOAs and densitometry (P<0.033). Postoperative anterior HOAs and densitometry (0-2mm) negatively affected 6 months BSCVA (P<0.021). Anterior corneal HOAs did not change from preoperative to 6 month after DMEK (P=0.649), while total posterior HOAs (RMS 3rd to 6th Zernike order), and densitometry decreased (P<0.001).


Anterior and posterior corneal HOAs, as well as corneal densitometry were elevated in eyes suffering from FED and remained higher throughout 6 months after DMEK. If present, anterior surface irregularities and anterior corneal haze may be the most important limiting factors in visual rehabilitation after DMEK.

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