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DSPEK Descemet’s stripping pseudo endothelial keratoplasty

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Session Details

Session Title: Cornea Surgical I

Session Date/Time: Monday 15/09/2014 | 08:00-10:30

Paper Time: 08:06

Venue: Boulevard B

First Author: : O.Daphna ISRAEL

Co Author(s): :    A. Marcovich   I. Bahar           

Abstract Details


Feasibility test, DSPEK: is an operation similar to DSAEK in which the implant is an artificial fluid barrier (silicon layer) that serve as a pseudo-endothelium at the posterior surface of the cornea.


Israel Pharmaseed Laboratory


Animal models. 18 rabbits underwent descemet stripping in there left eye, in 13 rabbits we implanted an 8-10.5 mm silicon layer using an air bubble for its attachment, in a similar way to DSAEK operation.5 rabbits were left as a control. Follow up was 1-16 weeks and still ongoing. We used Slit-lamp, pachymetry, histology and OCT for the follow up.


The average corneal thickness prior to surgery was 374 microns, the average corneal thickness of the control eyes was 1250 microns, out of the 13 treated eyes 5 were primary failure due to implant detachment, 4 rabbits maintained a cleared cornea for a week, followed by corneal edema, 4 rabbit maintained a clear cornea up to 16 weeks. 4 rabbits demonstrated a remarkable recovery of corneal edema following implant exchange, there was no apparent inflammatory reaction during the follow up in the tested eyes.


The results suggest a possibility of using a fluid barrier as a substitute for endothelium in the treatment of corneal edema. As long as there was attachment of the implant we have observed a positive effect. Larger group samples and longer period of observation is needed.

Financial Interest:

One or more of the authors... receives consulting fees, retainer, or contract payments from a company producing, developing or supplying the product or procedure presented

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