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Six-month results of accelerated corneal cross-linking (CXL) using an increased total dose of 7.2 J/cm2 with dextran-free isotonic riboflavin solution

Poster Details

First Author: E.Can TURKEY

Co Author(s):                        

Abstract Details


To report the efficacy of accelerated corneal crosslinking (CXL) using an increased total dose with dextran-free isotonic riboflavin solution


Ondokuz May�Ä�±s University, Department of Ophthalmology, Samsun/TURKEY


The accelerated CXL treatments (KXL system) were performed using a 10-minute riboflavin 0.1% (Vibex Rapid) with hydroxylpropyl methylcellulose (HPMC) soak and a 10-minute ultraviolet-A (UVA) irradiance at a level of 12 mW/cm2. This corresponds to a total radiant exposure of 7.2 J/cm2. Preoperative and 1, 3, and 6 months postoperative examinations were performed.


The study enrolled 25 eyes of 25 patients. The mean uncorrected distance visual acuity showed a statistically significant improvement, from 0.49 �Â�± 0.27 logMAR preoperatively to 0.28�Â�±0.30 logMAR 6 months postoperatively (P<.01). The mean keratometry readings also changed significantly. There were no statistically significant changes in the endothelial cell density between preoperatively and postoperatively.


We observed that new riboflavin formulation using an increased total dose of 7.2 J/cm2 seems to be quite efficient to treat and halt the progression of keratoconus without significant endothelial toxicity and may be the standard therapeutic protocol in the future.

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