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Microperimetry changes in age-related macular degeneration subjects implanted with the iolAMD Eyemax extended macular vision intraocular lens

Poster Details

First Author: S.Robbie UK

Co Author(s):    B. Qureshi                    

Abstract Details

Purpose:

The iolAMD Eyemax mono (Eyemax; London Eye Hospital Pharma) is the first of a new class of intraocular lens designed to optimise the image provided to the macula at eccentricities of up to 8 degrees from the foveal centre. To determine the effects of implantation on fixation stability and macular sensitivity we undertook baseline and post-operative microperimetry in subjects with age-related macular degeneration (AMD) and minimal cataract.

Setting:

London Eye Hospital, 4 Harley St, London UK

Methods:

8 eyes of 7 subjects with �â�‰�¤1 cataract, bilateral, advanced dry age-related macular degeneration (AMD) and preoperative corrected distance visual acuity �â�‰�¥0.60 (CDVA; LogMAR), underwent lens extraction and implantation with the iolAMD Eyemax mono - a single-piece, injectable, soft, hydrophobic acrylic intraocular lens for siting in the capsular bag. Initial follow-ups were undertaken at 1, 4 and 8 weeks with additional follow-up at 4-6 months in three eyes. Fixation stability and macular sensitivity were determined using microperimetry (MAIA, Ellex Medical Lasers Ltd.) using the �â�€�˜expert�â�€�™ algorithm to assess macular threshold sensitivity and fixation stability.

Results:

Mean threshold sensitivity increased from 8.3dB to 11.6dB at 2 months. The mean percentage of fixation points within a 4-degree circle increased from 81% to 91%. Preferred retinal loci in three eyes with extended follow-up were observed to shift progressively away from areas of geographic atrophy. In one subject, the average threshold sensitivity increased from 0dB to 16.6dB and mean percentage of fixation points within a 4-degree circle increased from 64% to 94%. In a second subject threshold sensitivity increased from 12.9dB to 27dB.

Conclusions:

In this cohort of patients with severe AMD and areas of geographic atrophy extending up to 8 degrees of retinal eccentricity, we found objective evidence to support significant improved visual function post-implantation with the Eyemax extended macular vision IOL. The results indicate that, even though cone densities are much lower at the peripheral macula than at the foveola, these photoreceptor populations targeted optically with extended macular vision technology can result in improved visual function.

Financial Disclosure:

has significant investment interest in a company producing, developing or supplying product or procedure presented, research is funded, fully or partially, by a company producing, developing or supplying the product or procedure presented

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