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Chromatic aberration and clinically relevant optical bench evaluations of intraocular lenses

Poster Details

First Author: C.Canovas THE NETHERLANDS

Co Author(s):    A. Alarcon   H. Weeber   J. Domingo   P. Piers           

Abstract Details


Optical bench evaluations of IOLs are strongly influenced by the metrics used, as well as by the conditions in which measurements are performed. Additionally, IOL material and design influence chromatic aberration, which impacts the optical and visual performance of the pseudophakic eye (Weeber et al. ARVO 2016). The purpose of this study was to evaluate the correlation between clinical performance and different measurement conditions and MTF based metrics.


AMO Groningen B.V., Groningen, Netherlands


Through focus MTF was recorded for different IOL technologies: an extended depth of focus IOL, monofocal (spherical and aspheric) as well as multifocals (with varying add powers). Measurements were performed in white light for a 3mm pupil. Three MTF based metrics were evaluated: the area under the MTF (MTFa) calculated up to 50cpmm, as well the MTF measured at 50cpmm and 100cpmm, respectively. In addition, MTF was recorded in green light at 50cpmm and 100cpmm, per ISO standard for IOLs (11979-2). Each metric was compared to the defocus curves measured in patients bilaterally implanted with the same IOLs.


The highest correlation with clinical defocus curves amongst all evaluated metrics was found for MTFa measured in white light (r2=0.95), while the lowest was for both MTF metrics that incorporate one single spatial frequency measured in green light (r2<0.60). For MTF at 100cpmm, the correlation increased by a factor of 1.1 when measurements were performed in white light, but remained relatively low (r2=0.67). The correlation of MTF at 50cpmm was further increased by a factor of 1.4 when using white light as compared to green light.


The correlation of MTF based metrics with clinical data depends on the measurement conditions. An MTF based metric measured in white light that incorporates multiple spatial frequencies up to 50cpmm showed the highest correlation to clinical performance. MTF metrics and measurements performed according conditions of the ISO standard resulted in limited correlation.

Financial Disclosure:

is employed by a for-profit company with an interest in the subject of the presentation

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