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Intraocular photobonding for accommodating intraocular lenses

Poster Details

First Author: N.Alejandre SPAIN

Co Author(s):    R. Gutierrez-Contreras   C. Dorronsoro   S. Marcos              

Abstract Details

Purpose:

Accommodating Intraocular Lenses (AIOLs) require a strong engagement of their haptics to the equatorial region of the emptied capsular bag in order to capture the forces from the ciliary muscle and change their surface shape and power. We recently demonstrated a photobonding method (Marcos et al. IOVS 2015) by which strips of capsular bag became strongly bonded to pHEMA polymer extraocularly. Here we present intraocular bonding of commercial IOL to capsular bag using Rose Bengal-Green light photobonding (RGP).

Setting:

Instituto de �Ã�“ptica Daza de Vald�Ã�©s. Spanish Research Council.

Methods:

After phacoemulsification a pHEMA-MMA IOL was inserted in the capsular bag. Continuous air infusion into the anterior chamber provided pressure and oxygen. The capsular bag and the IOL were stained a Rose Bengal solution. A 1-mm diameter fiber-optic probe connected to a custom-made lamp provided with a diode-laser (532 nm) was used to locally irradiate the capsular bag- IOL interface. Irradiance ranged from 10 -20 W/cm2 and was applied during 2.5 - 7 minutes. After specimen was mounted in an uniaxial stretcher to assess the bonding breaking load. The displacement/force curve was obtained for each specimen.

Results:

We found that irradiance/time of 20/2.5 &10/7 W/cm2 /min were sufficient for the IOL-capsular bag intraocular photobonding to happen. In the stretcher, the breaking force was above 0.12N, higher than the accommodating forces of the ciliary muscle (net force of 0.08N around the entire equator). The zonulae broke before the IOL-capsular bag bonding, suggesting that the bond would eventually resist the stretching of the ciliary muscles.

Conclusions:

Photobonding (RGP) of the capsular bag and IOL polymer material can be achieved intraocularly, in a cataract surgery procedure, compliant with the natural ciliary muscle stretching mechanisms. This technique will enable function of AIOLs without relying on capsular bag integrity or natural haptic fibrosis.

Financial Disclosure:

NONE

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