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In vivo analysis of age-related biometric changes during accommodation using high frequency ultrasound biomicroscopy (UBM)

Poster Details

First Author: A.Hipsley USA

Co Author(s):    D. Goldberg   E. Pfeiffer                 

Abstract Details

Purpose:

To measure and compare accommodation in young/healthy adult eyes to old/presbyopic adult eyes by exploring changes in the anterior segment anatomy using ultrasound biomicroscopy (UBM)�Â� imaging.

Setting:

Pilot Study; Private Clinic Atlantic Eye Surgeons, Little Silver , NJ, USA.

Methods:

Twenty eyes (10 patients) completed the study. Patients were split into 2 groups: Group 1 (Young/healthy): 27-32 years old; Group 2 (Old/Presbyopic): 45-55 years old. Dynamic accommodative response (AR) was stimulated utilizing a laser pointer as the far target and an ETDRS card fixed at 40cm as a near target. Biometric changes of AR in the anterior segment were measured by UBM in�Â� an accommodation-solicited condition and in a relaxation state as follows: a) scleral-ciliary angle structures; b) anterior and posterior (AP) lens surfaces c) lens thickness. Individual UBM images and raw data of video loops were analyzed.

Results:

We observed age-related changes in various intraocular distances. In the older/presbyopic eyes there were decreases in the distance between the ora serrata or the insertion zone identified previously as the �â�€�˜Posterior insertion zone of the Vitreous Zonule�â�€�™ (PIVZ) and (a) scleral spur, (b) the ciliary muscle apex; (c) the circumlental space as well as decreases in the relative AP movements of the lens surfaces during solicited accommodation.

Conclusions:

UBM can be used in vivo to dynamically observe and identify specific biomechanical relationships that are affected by age. This includes dynamic quantification of biometric changes in the scleral ciliary angle and AP lens surfaces. Almost all of the anatomical structures (both lenticular and extralenticular structures) appear to be affected by age and appear to contribute in uniquely to the age-related loss of accommodation that occurs with age.

Financial Disclosure:

gains financially from product or procedure presented, receives consulting fees, retainer, or contract payments from a company producing, developing or supplying the product or procedure presented

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