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Glutathione S-transferase expression in benign and malignant eyelid tumors

Poster Details

First Author: E.Koyun TURKEY

Co Author(s):    R. Karadag   S. Ozkanli   S. Oguztuzun   B. Bozer   I. Ozsoy   H. Bayramlar     

Abstract Details

Purpose:

To compare glutathione S-transferase (GST) levels in malignant and benign eyelid tumors in otherwise healthy individuals.

Setting:

Istanbul Medeniyet University School of Medicine

Methods:

We scanned pathology archives from October 2012 to April 2015for malignant eyelid biopsies, benign eyelid biopsies, and tissue removed during blepharoplasty and entropion operations. A total of 57 specimens were found. We divided the specimens into 3 group;malignant lesions, benign lesions, and controls (consisted of eyelid tissue removed during routine blepharoplasty).The pathology specimens were then stained using seven immunohistochemistry GST stains (GST-A, GST-P, GST-Z, GST-S, GST-K, GST-O, GST-T) and the intensity of staining was as graded from a scale of 0-3.

Results:

29 patients were female (50.8%). There were 13 patients in the malignant group, 20 patients in the benign group and 24 patients in the control group. Mean age was 66.0�ï�‚�±10.8 years in the malignant group, 62.4�ï�‚�±10.5 years in the benign group and 65.3�ï�‚�±11.1 years in the control group. In malignant group GST-O and GST-P staining was lower than the control group. In the benign group GST-P levels is lower than the control group. Differences among groups were statistically significant. There was no statistically significant difference between the intensity of staining in malignant and benign groups.

Conclusions:

GST levels can vary in eyelid tumors. In our study, GST-P level was lower in malign and benign groups, and GST-O level was lower in the malign group. This result suggests that these enzymes can play a significant role in eyelid carcinogenesis.

Financial Disclosure:

NONE

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