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Effect of oxidation stress caused by arsenic and UVA on the progress of cataract

Poster Details

First Author: S.Han SOUTH KOREA

Co Author(s):    S. Lee   I. Jun   K. Seo   S. Yoon           

Abstract Details

Purpose:

To evaluate the relationship between cataract and arsenic (As) due to oxidative stress, which mediates reactive oxygen species (ROS) followed by High-mobility group box 1(HMGB1)

Setting:

Yonsei University Severance Hospital, Seoul, South Korea

Methods:

In order to investigate whether cataract occurred during prolonged arsenic exposure and whether exposure to UVA accelerated cataract development. 8 weeks old B6 mice were divided into 4 groups of 10 each: Group A1 served as the control, group A2 was given 50 ppm sodium arsenite in their drinking water for 20 weeks, groups A3 were exposure to UVA three times weekly for 20weeks, groups A4 were exposure to UVA with given 50 ppm sodium arsenite in their drinking water.

Results:

The mice exposed to UVA or arsenite alone were induced cortical opacity (CO) type and posterior subcapsular opacity(PSCO) type, respectively, and the groups exposed to UVA and As together were induced both types of cataracts. In addition, when lens epithelial cells were exposed to arsenite, ROS generation and migration of HMGB-1 to the cytoplasm were observed. In case of using ROS quencher, there was decrease in UV or As induced HMGB1 secretion in lens epithelial cells.

Conclusions:

Considering that UVA or As causes cataract through oxidative stress, we have confirmed high HMGB1 translocation and ROS expression in mice and lens epithelial cell. Our findings therefore revealed a previously unknown mechanism of UV or As related to ROS and HMGB1 suggesting a new medical therapeutic target in Cataract .

Financial Disclosure:

NONE

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