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Hepatic triglyceride lipase gene polymorphisms (rs10468017, rs493258) association with macular pigment optical density in healthy patients

Poster Details

First Author: D.Cebatoriene LITHUANIA

Co Author(s):    A. Vilkeviciute   L. Kriauciuniene   R. Liutkeviciene              

Abstract Details

Purpose:

To determine LIPC rs10468017 and rs493258 genotypes associations with macular pigment optical density (MPOD) in ophthalmologically healthy participants of Lithuanian origin.

Setting:

1Lithuanian University of Health Sciences, Medical Academy 2Department of Ophthalmology, Lithuanian University of Health Sciences, Medical Academy

Methods:

102 participants (204 eyes) healthy subjects were included into our study. The optional macular pigment density module for the Visucam 500 used the reflectance of a single 460-nm wavelength based on a single blue-reflection fundus image to determine MPOD and its spatial distribution. The genotyping of rs10468017 and rs493258 was carried out using the real-time polymerase chain reaction method.

Results:

There were no significant differences between MPOD as a function of genotypes: LIPC rs10468017 CC (0.110�Â�± 0.022), CT (0.108�Â�± 0.018), TT (0.153�Â�± 0.188), p=0.840 and LIPC rs493258 CC (0.110�Â�± 0.022), CT (0.105�Â�± 0.017), TT (0.165�Â�± 0.192), p=0.082.

Conclusions:

Our results indicate that macular pigment deposition within the central retina does not dependent on genes (rs10468017, rs493258) involved in lipid metabolism in healthy people. This work was funded by a grant (No. SEN-11/2015) from the Research Council of Lithuania.

Financial Disclosure:

NONE

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