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The peripapillary retinal nerve fiber layer thickness and retinal ganglion cells complex thickness in early diagnosis of primary open-angle glaucoma using optical coherence tomography angiography - Optovue

Poster Details

First Author: A.Usman BELARUS

Co Author(s):    L. Marchenko   T. Kachan   A. Dalidovich              

Abstract Details


To evaluate the peripapillary retinal nerve fibers layer (RNFL) thickness and retinal ganglion cells complex (GCC) thickness in early detection of glaucomatous optic neuropathy (GON) using the optical coherence tomomgraphy Angiography (OCTA)


3rd Minsk City Clinical Hospital, Department of Ophthalmology, Belarusian State Medical University, Minsk, Belarus


Enrolled for the study were 23 patients (40 eyes) with stage I POAG (main group), 17 glaucoma suspects (24 eyes) and 10 healthy (20 eyes) control subjects with median age of 64,0 (58,0 �â�€�“ 74,0) 57,5 (44,0 �â�€�“ 60,0) 52,0 (51,0 �â�€�“ 53,0 retrospectively. All subjects underwent OCTA, (RTVue100 �â�€�œ�Ð�žptovue�â�€�) scanning of the retina using, respectively the 3.45mm ONH scan and 6 mm x 6mm GCC Thickness Map scans. Parameters analyzed were average total, average superior and average inferior thicknesses of the RNFL and the GCC.


The stage I POAG patients had significant decrease in all parameters of both the peripapillary RNFL and the GCC thicknesses as compared to the glaucoma suspect and control groups. Inter-group analysis using the Mann-Whitney criteria revealed statistically significant differences between the early glaucoma and the control group in only the superior and inferior thicknesses of the peripapillary RNFL while the two groups had statistically significant differences in all the parameters of the GCC. The highest Areas under the receiver operating characteristic curves (AUCs) were recorded in the GCC parameters (inferior thickness-0,994 and average total-0,968)


In early diagnosis of POAG, changes in GCC parameters have higher diagnostic significances than parameters of the paripapillary RNFL using the OCTA 'Optovue'

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