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XEN45 Gel Stent implant: outcomes of XEN implantation alone vs combined phacoemulsification-XEN surgery

Poster Details

First Author: N.Moura-Coelho PORTUGAL

Co Author(s):    S. Crisostomo   L. Costa   A. Basi�Â�­lio   M. Dutra-Medeiros   M. Sa Cardoso   T. Gomes     

Abstract Details


To evaluate and compare efficacy and safety of the XEN45 Gel Stent Glaucoma Treatment System (Allergan, Irvine, CA) implantation alone versus the combined Xen implantation and phacoemulsification (Phaco-Xen) in patients with medically refractory open-angle glaucoma (OAG).


The study was conducted at a tertiary center for Ophthalmology in Portugal, reporting the initial experience with XEN implantation at the national level.


Retrospective review of 19 eyes of 18 patients with OAG that underwent surgery at our institution, either Xen implant alone or combined Phaco-Xen. Clinical outcomes compared at 6-month follow-up included intra-ocular pressure (IOP) reduction, rate of IOP reduction, reduction in number IOP-lowering drug requirements, required additional procedures, and complications.


11 eyes underwent Xen implant alone, and 8 eyes underwent combined Phaco-Xen surgery. A significant reduction in IOP at 6-month post-surgery was observed in both Xen and Phaco-Xen patient groups (p-value = 0.019, p-value = 0.050, respectively). The median difference in IOP reduction between both groups was not statistically significant (p-value = 0.741), as were not the median rate of IOP reduction and the median reduction in IOP-lowering drug requirements post-operatively (p-value = 0.934 and p-value = 0.448, respectively). No major intra-operative or post-operative complications were observed; 3 patients in each group required additional procedures within the follow-up period.


In this study, XEN surgery showed good efficacy in IOP reduction and safety profiles in medically refractory open-angle glaucoma, either alone or combined with cataract surgery. Larger, prospective studies are encouraged to further assess whether associating cataract surgery to Xen implantation may have an added IOP-lowering benefit.

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