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Experimental scleral study after cross-linking exposure

Poster Details

First Author: A.Milingert RUSSIA

Co Author(s):    S. Borzenok   T. Sokolovskaya                 

Abstract Details


to determine morphological and bio-mechanical properties of scleral tissue after a cross-linking exposure in individuals with different types of axial refraction of the eye.


The S. Fyodorov Eye Microsurgery Federal State Institution, Moscow, Russia


the study included 16 isolated scleral fragments of 16 human cadaver eyes. The anterior-posterior axis (APA) of the studied eyes was 23.56�Â�±3.06mm (20.05-26.62). Samples of sclera (5x5mm) were cut out with a microsurgical blade from the posterior pole of the eye, and then were exposed to a cross-linking effect. Further, all the fragments of the sclera were cultivated in a nutrient medium. Biomechanical tests of samples of scleral tissue after the cross-linking exposure was performed using the universal testing Instron-3322 machine. Then the samples of scleral tissue was investigated using the raster ion-electron microscope Quanta 200 3D.


An increase in strength indices and Young's Modulus were noted in all tissue samples, after cross-linking within the study of biomechanical properties of fragments of scleral of posterior pole of the eye.The strength indices of scleral tissue after the crosslinking exposure increased significantly (p<0.05) from 13.4�Â�±1.3 to 20.2�Â�±1.2Mpa in eyes with a hyperopic type, from 9.8�Â�±1.4 and 14.7�Â�±1.3 Mpa �â�€�“ with a myopic type, from 12.2�Â�±1.3 to 19.8�Â�±1.5 MPa �â�€�“ with emmetropia. Morphological investigations of the sclera showed decreasing the distance between the bundles of collagen fibrils and the formation new of adhesive collagen structures in its superficial layers.


Crosslinking leads to pronounced morphological changes of the sclera, that is accompanied by an in crease of the strength characteristics of the tissue. 2. It is possible to develop a method of the impact on the fibrous tunic of the eye in open-angle glaucoma to stabilize the course of disease modeling the biomechanical properties in the most predictably dangerous areas

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