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Optic nerve head morphology in glaucomatous and nonglaucomatous optic nerve cupping

Poster Details

First Author: M.Aghsaei Fard IRAN

Co Author(s):    S. Moghimi                    

Abstract Details


Enlargement of optic disc cupping is seen both in glaucoma and neurologic disorders. In this study we compared optic nerve head (ONH) morphology of cupping between eyes with primary open-angle glaucoma (POAG) and eyes with nonglaucomatous cupping using enhanced depth imaging (EDI) with spectral-domain optical coherence tomography (SD-OCT).


Farabi Eye Hospital, an academic institution


In this prospective study 31 eyes of 31 patients with moderate to severe POAG, 31 eyes of 16 patients with nonglaucomatous cupping (7 patient with compressive chiasmal tumor, 4 patients with methanol optic neuropathy, 2 patients with periventricular leukomalacia, two optic neuritis, and one traumatic optic neuropathy, all with more than 0.6 cup to disc ratio) and 28 healthy controls eyes were recruited. The optic discs were scanned using SD-OCT. Lamina cribrosa (LC) thickness, anterior LC depth (ALD) from Bruch�â�€�™s membrane opening, and prelaminar tissue thickness were determined and compared.


There was no significant difference in the cup to disc ratio and peripapillary retinal nerve fiber layer thickness between the POAG and nonglaucomatous cupping groups (p>0.99), but both groups had a significantly different from healthy group (p<0.001). POAG and nonglaucomatous eyes had greater ALD and thinner LC than control eyes in all regions (middle, superior, and inferior) of the ONH (p<0.001 for both). LC thickness, prelaminar thickness, and ALD of POAG eyes were not different from nonglaucomatous eyes (all P>0.99).


Thinning and posterior displacement of LC were observed both in POAG and nonglaucomatous cupping with similar cup to disc ratio and retinal nerve fiber loss. The thickness and position of LC seems to be independent of glaucomatous damage.

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