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Efficacy of azithromycin 1.5% eye drops on the signs and symptoms of patients with chronic blepharitis

Poster Details

First Author: Y.Altay TURKEY

Co Author(s):    M. Kocamaz   G. Demirok   Y. Topalak   P. Altiaylik Ozer   A. Sengun        

Abstract Details

Purpose:

To report the efficacy of azithromycin 1.5% eye drop plus eyelid hygiene and warm compresses in the treatment of chronic blepharitis.

Setting:

Ufuk University Faculty of Medicine, Department of Ophthalmology, Ankara

Methods:

Eighty-eight patients diagnosed with chronic blepharitis were randomly assigned to two groups. Both groups received azithromycin 1.5% eye drops twice daily for the first 2 days then group 1 (43 patients) followed by once daily for the next 12 days, and group 2 ( 45 patients) followed by once daily for the next 28 days. Patients were evaluated at study initiation, at the end of treatment and 1 month after the end of the treatment. At each visit symptoms and signs graded according to the severity and tear break-up time (TBUT) and Schirmer test values were recorded.

Results:

At the end of treatment all patients demonstrated significant improvements in the ocular symptoms, signs, TBUT and Schirmer�â�€�™s test values from baseline. Between the groups, group 2 showed a significantly better and long-lasting improvement in terms of lid margin debris, meibomian gland (MG) expression, MG secretion scores and Schirmer�â�€�™s test values.(p= 0.0001, p=0.02, p=0.01, and p=0.001 respectively)

Conclusions:

Azithromycin 1.5% eye drop in combination with warm compresses are effeective in treating the signs and symptoms of chronic blepharitis and the one month treatment duration shows better and long-lasting improvement than two week treatment duration.

Financial Disclosure:

NONE

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