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Effect of collagen cross-linking in arresting the progression of keratoconus amongst the Omani population: our experience

Poster Details

First Author: L.Tulasiram OMAN

Co Author(s):    R. Al Saeidi   A. Alugail   D. Deshmukh   N. Raj Mohan           

Abstract Details


To know the effect of collagen cross linking (CXL) in arresting the progression of keratoconus (KC).


Armed Forces Hospital, Al Khoudh, Muscat, Sultanate of Oman.


214 cases who were included in the study underwent corneal topography (Nidek corneal topographer) for Kmax and Spectral domain OCT (SD �â�€�“ OCT) for central corneal thickness (CCT) at the base hospital. All patients underwent standard CXL using 0.1% Riboflavin in hydroxypropyl methylcellulose (Viber Rapid, Avedro Inc) that was administered for 10 minutes after debridement of corneal epithelium. Cornea was exposed to 365 nm UVA light for 4 minutes using Avedro machine at an irradiance of 30mW/cm2. Patients were followed up at 3 months, 6 months and 1 year.


Mean age of presentation was 17 years with a male preponderance (59.62%). Significant reduction in Kmax of 3.14 D (p < 0.05) was noted in majority (189, p < 0.0001) of the cases at the end of 1 year after CXL. About 47% of cases did not show any change in CCT and 16% of them showed an increase in CCT. Unaided visual acuity showed a marginal improvement post operatively in 62 cases (28.97%, r < �.3), whereas patients fitted with contact lenses (scleral / RGP) after CXL showed a marked improvement in vision compared to those without treatment.


Collagen cross linking was effective in arresting the progression of KC with minimal side effects and risk factors when compared to other modalities of treatment.

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