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Effect of collagen cross-linking in arresting the progression of keratoconus amongst the Omani population: our experience

Poster Details

First Author: L.Tulasiram OMAN

Co Author(s):    R. Al Saeidi   A. Alugail   D. Deshmukh   N. Raj Mohan           

Abstract Details

Purpose:

To know the effect of collagen cross linking (CXL) in arresting the progression of keratoconus (KC).

Setting:

Armed Forces Hospital, Al Khoudh, Muscat, Sultanate of Oman.

Methods:

214 cases who were included in the study underwent corneal topography (Nidek corneal topographer) for Kmax and Spectral domain OCT (SD �â�€�“ OCT) for central corneal thickness (CCT) at the base hospital. All patients underwent standard CXL using 0.1% Riboflavin in hydroxypropyl methylcellulose (Viber Rapid, Avedro Inc) that was administered for 10 minutes after debridement of corneal epithelium. Cornea was exposed to 365 nm UVA light for 4 minutes using Avedro machine at an irradiance of 30mW/cm2. Patients were followed up at 3 months, 6 months and 1 year.

Results:

Mean age of presentation was 17 years with a male preponderance (59.62%). Significant reduction in Kmax of 3.14 D (p < 0.05) was noted in majority (189, p < 0.0001) of the cases at the end of 1 year after CXL. About 47% of cases did not show any change in CCT and 16% of them showed an increase in CCT. Unaided visual acuity showed a marginal improvement post operatively in 62 cases (28.97%, r < �.3), whereas patients fitted with contact lenses (scleral / RGP) after CXL showed a marked improvement in vision compared to those without treatment.

Conclusions:

Collagen cross linking was effective in arresting the progression of KC with minimal side effects and risk factors when compared to other modalities of treatment.

Financial Disclosure:

NONE

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