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Corneal biomechanics after accelerated cross-linking: comparison between 18 mW/cm2 and 9 mW/cm2 protocols

Poster Details

First Author: F.Rezvan IRAN

Co Author(s):    H. Hashemi   S. Asgari   S. Mehravaran   M. Miraftab   R. Ghaffari   A. Fotouhi     

Abstract Details


To determine and compare one-year corneal biomechanical changes after ACXL in progressive keratoconic patients undergoing ACXL protocols (18mW/cm2� minutes vs. 9mW/cm2� minutes).


1. Noor Ophthalmology Research Center, Noor Eye Hospital, Tehran, Iran 2. Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran


In this non-randomized clinical trial, cases in both groups were examined with the Corneal Visualization Scheimpflug Technology (Corvis-ST) at baseline and at 6 and 12 months after treatment. Extracted indices included intraocular pressure (IOP), corrected IOP, central corneal thickness (CCT), first and second applanation times, lengths, and velocities (T1, T2, L1, L2, V1, and V2), highest concavity time (HCT), deformation amplitude (DA), peak distance between bending points (PD), and radius of curvature.


Mean patient age in the 5-minute and 10-minute groups was 23.3�Â�±5.7 and 22.4�Â�±6.0 years (P=0.580), and mean baseline maximum keratometry, CCT and IOP was 46.6�Â�±2.2 and 47.6�Â�±2.1 diopters (D) (P=0.162), 495.0�Â�±28.1 and 467.6�Â�±22.5�Î�¼m (P=0.003), and 12.6�Â�±1.9 and 12.8�Â�±2.1mmHg (P=0.824), respectively. After adjusting for CCT and baseline values, at one year after the procedure, IOP (13.03�Â�±1.45 vs. 12.21�Â�±1.56mmHg, P=0.034) and T1 were higher in the 5-minute group (6.83�Â�±0.21 vs. 6.68�Â�±0.22ms, P=0.036), but T2 (21.34�Â�±0.28 vs. 21.58�Â�±0.28ms, P=0.007), HCT (16.98�Â�±0.59 vs. 16.36�Â�±0.57ms, P=0.017), and DA (1.04�Â�±0.09 vs. 1.09�Â�±0.08mm, P=0.028) were lower.


After cross-linking in cases of mild and moderate keratoconus, corneal biomechanics appear stable or stronger with both 5- and 10-minute protocols. However, early cases who had the 5-minute method showed better improvement in corneal biomechanic indices.

Financial Disclosure:


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