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Straylight in keratoconus patients submitted to collagen cross-linking: conventional vs iontophoresis

Poster Details

First Author: G.Monaco ITALY

Co Author(s):    M. Gari   A. Scialdone                 

Abstract Details


The aim of the study was to compare the short-term variation of straylight in patients with keratoconus submitted to collagen corneal cross-linking (CXL).


ASST Fatebenefratelli Sacco, Milan (Italy)


The study was prospective, comparative, and randomized. Twenty eyes of 20 patients with progressive keratoconus were randomized into two groups: group A was submitted to conventional CXL (10 eyes), group B to iontophoresis CXL (10 eyes). All participants were analyzed pre-treatment, and post-treatment on 3 days, every week for 1 month, on two months and three months. The main outcome measure was the value of the logarithmic straylight value [log (s)] measured using a straylight meter (C-Quant�â�„�¢, Oculus Optikger�Ã�¤te GmbH, Wetzlar, Germany). We also evaluated the best corrected visual acuity (BCVA[logMAR]), the keratometry readings (K1, K2, Km, and Kmax), the manifest spherical equivalent refraction (D), the central corneal thickness (CCT, micrometers), and the endothelial cell density (ECD).


The retinal straylight in patients undergone to conventional CXL was pretreatment 1.16 (�Â�± 0,19), on 3 days after CXL was 1,44 (�Â�± 0,15), on 1 month was 1,28 (�Â�± 0,21) and on three months 1,15 (�Â�± 0,21); the retinal straylight in patients undergone to iontophoresis CXL was pretreatment 1,21 ( �Â�± 0,21), on 3 days after I-CXL was 1,33 (�Â�± 0,20), on 1 month was 1,09 (�Â�± 0,16) and on three months 1,05 (�Â�± 0,18) (p<0.05). No differences in BCVA, K readings, refraction, and ECD were found between groups. CCT was statistically reduced in the group A (p<0.05).


The data indicate a statistically significant worsening of the straylight values starting from the third postoperative day (p<0.01) in both groups but patients submitted to iontophoresis CXL had an improvement in straylight compared to preoperative data.

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