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Conventional vs accelerated corneal cross-linking in the treatment of keratoconus: a medium-term randomized study

Poster Details

First Author: H.Khairy EGYPT

Co Author(s):    K. Said-Ahmed   A. Zaky   H. Elkashory              

Abstract Details


The aim of the study is to compare outcome of accelerated versus Conventional corneal Collagen Cross Linking (CXL) for treatment of progressive keratokonus.


Menoufia University Hospitals, Menoufia, Egypt


This was patients masked, randomized, controlled comparison trial involving 60 eyes of 35 patients with evidence of progressive Keratokonus and Corneal thickness greater than 400 um. Patients were randomized to receive either standard CXL (3 mW/cm2, 30 minutes), or accelerated CXL (18 mW/cm2, 5 minutes). The main outcomes were the change in; Maximum-K reading, manifest refractive spherical equivalent, central corneal thickness (CCT), and the best corrected visual acuity (Log Mar).


At the end of 12 months follow-up time, the CCT showed no significant change from 422�Â�±5.17�Â�µm preoperatively to 419�Â�±4.45�Â�µm (p=0102). The maximum-K reading has decreased significantly from 49.19�Â�±2.30 D preoperatively to 46.96�Â�±6.03 D postoperatively (p<0.05). The mean manifest spherical equivalent showed no significant change from 4.04�Â�±1.51 D preoperatively to 4.17�Â�±1.63 D postoperatively (p=0.110). The mean best corrected visual acuity showed no significant change from 0.29�Â�±0.12 preoperatively to 0.31�Â�±0.11 postoperatively (p=0.110).


The Accelerated CXL is as effective as Conventional CXL in the treatment of progressive Keratokonus.

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