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Scotopic contrast sensitivity and glare after accelerated corneal cross-linking

Poster Details

First Author: S.Asgari IRAN

Co Author(s):    H. Hashemi   A. Mohamadi   E. Jafarzadehpur   M. Miraftab   S. Shahhoseini   A. Fotouhi     

Abstract Details


To assess one-year changes in uncorrected and corrected contrast sensitivity (CS) and glare under scotopic conditions after accelerated cross linking (CXL) using the 18mW/cm2 protocol for the treatment of progressive keratoconus and compare results with un-operated controls.


Noor Research Center for Ophthalmic Epidemiology, Noor Eye Hospital, Tehran, Iran


In this non-randomized clinical trial, 30 eyes were enrolled in the CXL group and 30 were assigned to the control group. Scotopic CS at spatial frequencies (SF) of 0.5, 1.1, 2.2, 3.4, 7.1, and 15 cycles per degree (cpd) was assessed using the MonCv3 System (Metrovision, France) under scotopic conditions (0.5 lux) at baseline and at 6 and 12 month follow-up visits.


Mean age in both groups was 24.32�Â�±5.17 and 30.93�Â�±7.43 years, respectively (P<0.001). Changes in uncorrected and corrected CS and glare were similar in the two groups (all P>0.05) except for corrected CS at SF 7.1 cpd (1.45�Â�±4.31 vs. 3.21�Â�±4.69 dB, P=0.010) and 15 cpd (1.12�Â�±4.63 vs. 3.03�Â�±5.48 dB, P=0.007). Based on covariate analyses, corrected CS3.4 at 1 year after CXL reduced in those with better baseline values (P<0.001). Corrected CS7.1 and CS15 were related to CXL and their baseline values (all P<0.050). Uncorrected CS in all SFs and uncorrected and corrected glare were related to their preop values (all P<0.001).


Accelerated CXL can reduce scotopic corrected CS at SFs higher than 7cpd in cases with better baseline values of these parameters. Changes in uncorrected CS and glare are only a factor of baseline values and the indices reduce in cases with better baseline values after one year.

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