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Corneal cross-linking for progressive keratoconus: long-term results

Poster Details

First Author: P.Arriola-Villalobos SPAIN

Co Author(s):    J. Almendral-Gomez   D. Diaz-Valle                 

Abstract Details


To evaluate the long-term efficacy and safety of corneal cross-linking (CXL) in progressive keratoconus.


Ophthalmology Department. Hospital Clinico San Carlos, Madrid. Spain.


A prospective, uncontrolled interventional case series study was carried out in subjects with progressive keratoconus who underwent standard epithelium-off CXL. Efficacy outcome measures were changes in keratometric, morphological and topographic corneal values, registered with Oculus Pentacam. Ocular complications were recorded. Mean follow-up was 4�Â�±2.24 years


The 30 patients (22 men) enrolled were aged 12 to 52 years (mean age 32,3�Â�±10,01). . 12 eyes reached at least six years of follow up. At that follow-up time, there was no significant change in topographic astigmatism [preoperative=4,371,62 diopters (D) vs. postoperative=3,972,06 D, P=0,304] but a significant change in mean keratometry (473,3 D vs. 45,782,98 D, P=0,002). In three eyes (10%), keratoconus had progressed more than 1.0 D by the last follow-up visit while in seven eyes (23,33%) mean K had decreased more than 1.0 D. There was no sight-threatening complication in any patient eye.


This long-term follow-up study suggest that CXL is a safe and effective procedure to prevent keratoconus progression. However, disease progression occurred in 10% of the treated eyes.

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