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Long-term visual, refractive, topographic and tomographic results of standard epi-off corneal cross-linking in patients with progressive keratoconus

Poster Details

First Author: E.Albe ITALY

Co Author(s):    P. Vinciguerra   F. Claudia                 

Abstract Details


To evaluate visual, refractive, topographic and tomographic outcomes 10 years after standard epi off corneal collagen crosslinking (CXL) in the management of progressive keratoconus.


Department of Ophthalmology, Istituto Clinico Humanitas, RozzanoMilano, Italy.


46 eyes (age between10 and 52 years) underwent CXL from 2006 to 2015 with the standard (Dresden) CXL protocol . Uncorrected and best spectacle corrected distance visual acuity (UCVA and BSCVA), manifest refraction, slitlamp biomicroscopy, corneal topography and tomography, endothelial cell counts and demarcation line were evaluated at baseline and at all postoperative followup examinations until 10 years postoperatively


The mean improvements in UCVA and BSCVA were statistically significant from the second year postoperatively, remaining stable up to 10 years follow-up. The mean Kmax decreased from 59.4D to 53.4D after 6 years postoperatively, remaing stable up to 10 years. Central corneal thickness significantly decreased up to three years postoperatively, gaining a mean of 20 microns on average up to 10 years postoperatively after the initial reduction. No significant variation in endothelial cell count were observed


Standard epi off CXL stops keratoconus progression up to 10 yeras after treatment, is a safe procedure and is effective in improving UCVA and BSCVA by flattening the cornea and reducing the corneal asimmetry. These data suggest the potential preventive use of the procedure at the first initial keratoconus diagnosis.

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