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Chemical corneal de-epithelization: a simple, safe and effective surgical adjuvant procedure on early diagnosis acanthamoeba keratitis management

Poster Details

First Author: S.Pinho PORTUGAL

Co Author(s):    P. Cardoso   J. Pinheiro Costa   L. Torr�Ã�£o   R. Moreira   F. Falc�Ã�£o-Reis        

Abstract Details


Acanthamoeba Keratitis (AK) is a potentially sight-threatening infection more common among contact lenses (CL) users. The prevalence has been increasing in the recent years. The poor prognosis is often related to a significant delay in diagnosis and to a lack of effecttive treatment. The purpose is to determine the therapeutic outcomes of adjuvante chemical corneal de-epithelization approach on early diagnosed AK.


A retrospective study. Centro Hospitalar S�Ã�£o Jo�Ã�£o.


Six patients (6 eyes) with early diagnose of AK were enrolled between 2016 and 2017. Diagnosis was made based on clinical manifestations and confirmed by positive polymerase chain reaction (PCR) test result. 40% ethanol-balanced salt solution was aplied on corneal surface for 30 seconds to induce corneal de-epithelization. The cornea was dried using synthetic sponges and balanced salt solution was used to wash out residual alcohol remnants. Melted epithelium was then removed. Follow-up was made at day 1, week 1 and then monthly.


All patients (100%) had favorable clinical response with good visual acuity results. No recurrences or complications were reported.


AK is an important diagnosis to remember and consider in all cases of LC keratitis. Early diagnosis and treatment is essential to ensure a good visual outcome. Chemical corneal de-epithelization may be a simple and safe adjuvant treatment to successfully early management of AK.

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