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Clinical feature of corneal opacity and outcome of penetrating keratoplasty in patients with primary congenital glaucoma

Poster Details

First Author: Y.Kim SOUTH KOREA

Co Author(s):    J. Kim   J. Jeoung   M. Kim   K. Park   W. Wee   J. Oh     

Abstract Details


To investigate the characteristics of corneal abnormalities and the clinical outcome of penetrating keratoplasty (PKP) in patients with primary congenital glaucoma.


Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.


Medical records of 320 eyes from 193 patients who were visited with primary congenital glaucoma in our department between January 1976 and January 2016 were reviewed retrospectively. Among them, the patients who had grade 4 corneal opacity affecting visual impairment underwent PKP. The survival rates and median survival time of corneal grafts were evaluated and the impact factors on graft failure were analyzed.


Among 320 eyes, corneal opacification was seen in 195 eyes (60.1%) including nebulomacular opacity in 128 eyes, leukomatous corneal opacity in 67 eyes. Twelve eyes of 10 patients underwent penetrating keratoplasties. The success of the PKP was achieved in 6 eyes (50%) and graft failure occurred in other 6 eyes due to graft rejection in 4 eyes and infection in 2 eyes. The overall mean graft survival time was 11 months. Small recipient cornea (diameter < 11 mm) and concurrent glaucoma valve surgery were significantly correlated with graft failure (P = 0.04 and P = 0.05, respectively).


The overall graft survival rate of PCG was 50%. Small recipient cornea and concurrent glaucoma valve surgery were associated with a poorer graft survival.

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