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Combined treatment including superficial lamellar keratectomy, phototherapeutic keratectomy and mitomycin C for Salzmann�â�€�™s nodular degeneration

Poster Details

First Author: S.Farrokhi GERMANY

Co Author(s):    M. Spitzer   J. Steinberg   T. Katz   S. Linke           

Abstract Details


To evaluate the treatment outcomes (safety and efficacy) of manual superficial keratectomy, phototherapeutic keratectomy (PTK) and subsequent off-lable use of intra-operative application of mitomycin C (MMC) for Salzmann nodular degeneration (SND).


University Eye Clinic Hamburg-Eppendorf, Germany


This retrospective study included patients diagnosed with Salzmann�â�€�™s nodular degeneration without ocular co-mobidities. Pre- and postoperative examination included autorefraction and subjective refraction for distance-corrected visual acuity (DCVA), slit lamp biomicroscopy, digital photography, corneal topography and anterior segment OCT. Epithelial removal was achieved 20% alcohol assisted and lamellar superficial dissection of Salzmann�â�€�™s nodules was then performed. A 193-nm Ar-F excimer laser (Allegretto 200; WaveLight AG, Erlangen, Germany) was used for PTK with 7mm optical zone and 15�Î�¼m ablation. Mitomycin C 0.02% was applied afterwards for 30 seconds. All patients were followed-up for at least 6 months.


In total 50 eyes of 44 patients were included. Treatment of SND led to a significant increase of DCVA by average of four reading lines (far distance) up to ten reading lines (p<0.001), as well as dramatic reduction of hyperopia (myopic shift). Furthermore during follow-up, corneal topography showed regularization of astigmatism and all corneas appeared clear on slit lamp examination.


This study confirms that the combined treatment including manual superficial keratectomy, PTK, and adjunctive MMC led to a significant and consistent improvement of visual acuity and quality in treated eyes.

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