Lisbon 2017 Delegate Registration Programme Exhibition Virtual Exhibition Satellites OneWorld Travel Discount
escrs app advert

Posters

Search Title by author or title

An artificial corneal endothelial implant in animal models: 4 years' experience

Poster Details

First Author: O.Daphna ISRAEL

Co Author(s):                        

Abstract Details

Purpose:

To evaluate the safety and efficacy of an artificial implant for the treatment of corneal edema secondary to endothelial failure.

Setting:

Animal model

Methods:

A thin silicone membrane with an adhesive coating was implanted on the posterior cornea of 17 rabbits and 23 pigs from which 17 rabbits and 11 pigs Descemet�â�€�™s membrane and endothelial cells had been removed, in 12 pigs the endothelial layer wasn�â�€�™t removed. 16 animals serve as control. Slit lamp examination and corneal thickness (CT) measurements were performed for up to one year.

Results:

As long as the implant is attached corneal edema was completely cleared. There was high incidence of implant partial detachment leading to recurrence or partial recurrence of corneal edema. Other complication: One case of corneal perforation, one case of corneal ulcer that healed with topical antibiotic.

Conclusions:

An artificial silicone implant could provide an alternative to endothelial keratoplasty that would not utilize human tissue, will require less immunosuppressive medications, and could easily be implanted through a small corneal incision. Most common complication was implant detachment which is partially due to the nature of the animal model.

Financial Disclosure:

has significant investment interest in a competing company, receives consulting fees, retainer, or contract payments from a company producing, developing or supplying the product or procedure presented

Back to Poster listing