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Role of therapeutic contact lens in epithelial healing following Descemet�â�€�™s stripping automated endothelial keratoplasty: an RCT

Poster Details

First Author: T.Agarwal INDIA

Co Author(s):    R. Mukhija   P. Maharana   R. Sinha   N. Sharma   J. Titiyal        

Abstract Details


To study the efficacy and safety of therapeutic contact lens (TCL) and corneal epithelial healing pattern in patients undergoing DSAEK in patients undergoing Descemet�â�€�™s stripping automated endothelial keratoplasty (DSAEK).


Dr. R.P. Centre for Ophthalmic Sciences All India Institute of Medical Sciences New Delhi India


40 eyes of 40 patients with pseudophakic bullous keratopathy undergoing DSAEK were randomly allocated into 2 groups, control (no TCL) and test (TCL). Patients were followed up daily till complete re-epithelization of the cornea was noted and then subsequently at 1 week, 1 month and 3 months. Primary outcome measure was time taken (in days) for epithelial healing and secondary outcome measures were post-operative pain score, graft attachment, best spectacle corrected visual acuity and endothelial cell loss at 3 months.


Average time for epithelial healing was 3.35�Â�±0.49 days in the test group and 4.95�Â�±1.05 days in the control group (P<0.001). Post-operative pain scores were significantly lower in the test group as compared to the control group (P<0.001). Graft detachment rates were higher in the control group (40%) than the test group (10%) (P=0.03). Average endothelial cell loss at 3 months was 18.59% in the test group and 22.09% in the control group (P=0.06). No contact lens related adverse effects were noted during the study period.


Use of a Therapeutic Contact Lens (TCL) in the post operative period following DSAEK leads to significantly faster corneal epithelial healing and lesser postoperative pain. Graft detachment and rebubbling rates are significantly reduced with the use of TCL. Endothelial cell loss is also lesser when TCL is used after DSAEK.

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