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A typical Terrien's marginal degeneration: review of 2 cases

Poster Details

First Author: R.Yela Delgado SPAIN

Co Author(s):    M. Pascual Gonzalez   L. Ibares Frias   J. Da Saude Lourenco   C. Colliga Jimenez   P. Balado Vazquez   B. Garcia-Valcarcel Gonzalez     

Abstract Details


To describe two cases of Terrien's marginal degeneration (TMD) with atypical features: a pediatric patient that presented with unilateral autosealed corneal microperforation and a patient with bilateral Terrien disease of inferior distribution.


Both patients are followed up in our ocular surface and cornea clinic at Hospital General Universitario Gregorio Mara�Ã�±�Ã�³n, Madrid, Spain.


Extensive review of clinical and photographical documentation of both patients, as well as a comprehensive review of the available literature.


Patient 1: A 9 year-old male patient presented with an episode of autosealed corneal microperforation in his right eye (RE), treated successfully with a contact lens and without requiring any surgical intervention. Biomicroscopy showed a thinned area superiorly with lipoid deposition and vascularization in RE. Patient 2: A 80 year-old patient with background of epirretinal membrane and TMD in both eyes was referred for follow up. He presented a 360-degree peripheral lipoid corneal degeneration in his left eye and similar findings of exclusively inferior distribution in RE, with thinning of more than half the corneal thickness and associated ectasia.


Terrien's marginal degeneration is a rare disease characterized by progressive thinning of the peripheral cornea and is associated with corneal neovascularization, opacification and lipid deposition. Although TMD typically begins superiorly, is more common in men and usually bilateral but asymmetrical, aytipical forms may occur as in the two cases hereby presented: a case of inferior distribution and a pediatric case that presented as an autosealed corneal microperforation.

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