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Cyclosporine A in the treatment of patients with severe dry eye

Poster Details

First Author: E.Mrukwa-Kominek POLAND

Co Author(s):    M. Nowak   R. Kinasz   A. Urgacz-Lechowicz              

Abstract Details

Purpose:

The aim of this presentation is to assess the effectiveness and the benefits of eye drops with Cyclosporin A in the treatment of severe dry eye syndrome

Setting:

Department of Ophthalmology, Prof Gibinski University Clinical Center, Medical University of Silesia, Katowice, Poland

Methods:

10 patients (7 female and 3 male patients) was referred to the corneal unit of University Clinical Center in Katowice because of severe symptoms of dry eye. Patients received symptomatic treatment for 3-6 years, with no success. The patients were administered eye drops cyclosporine (1mg/1ml, Ikervis, Santen) once a day, one drop into each eye. There were assessed changes in: BCVA, IOP, Meibomian Gland Dysfunction, corneal staining, confocal microscopy images, Ocular Surface Disease Index (OSDI), patients satisfaction questionaire

Results:

In 6 patients one-week after cyclosporine introduction the improvement in clinical state, decrease in fluorescein staining of the corneal surface and reduction of OSDI from 60 to 52 points were observed. After 2 months the patient quality of life improved significantly. After 3 months mean BCDVA increased from 0.6 to 0.8. Confocal microscopy revealed apparent distortions in the keratocytes arrangement, folds in the deep stroma and multiple subepithelial deposits. Mean OSDI was 38 points after 2 months and 24 after 6 months. Eight patients continue treatment with CsA longer than 6 months

Conclusions:

The benefits with Cyclosporin A in the new technology are its ability to improve ocular surface damage and reduce inflammation in patients with severe dry eye syndrome

Financial Disclosure:

receives consulting fees, retainer, or contract payments from a competing company

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