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Keratoconus progression detected at short-term follow-up and associated risk factors

Poster Details

First Author: M.Henriquez PERU

Co Author(s):    M. Rincon   J. Mejias   L. Izquierdo              

Abstract Details

Purpose:

To evaluate visual, refractive, and tomographic changes in progressive and no progressive keratoconus at 3 months follow-up and to determinate risk factors associated to progression.

Setting:

Research Department, Oftalmosalud Instituto de Ojos, Lima, Peru.

Methods:

This prospective cohort study included 106 eyes with new keratoconus diagnosis between July 2012 and January 2017. Scheimpflug imaging analysis, visual acuity and refraction at the time of diagnosis and 3 months after was performed. Progression was defined as an increase in the steeper keratometry (Kmax) of 1.0 Diopter (D) at 3 months of follow-up. Wilcoxon test as non-parametric and T-student test as parametric alternative were used, risk ratio, and odds ratio were calculated to detect risk factors associated to progression.

Results:

14 eyes (13.20%) experienced progression at 3 months of follow-up. Mean change in Kmax in the progressive group and no progressive group was �.34D and -0.32 respectively (p<. 001), mean change in astigmatism in progressive and no progressive group was 1.00D y �.11D respectively (p=0.03). Mean change in the Index of surface variance (ISV) was �.28 �Î�¼m in the progressive and -0.41�Î�¼m (p<. 001) in the no progressive. An increase of 7 �Î�¼m in ISV at 3 months showed an AUROC of 0.97, (RR= 16.42, p<. 001) and an increase in astigmatism > 0.7D had a RR=7.5 (p=0.001).

Conclusions:

Progression can be assessed at short-term follow up. Index of surface variance and astigmatism are predictive factors for progression.

Financial Disclosure:

NONE

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