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Keratoconus progression detected at short-term follow-up and associated risk factors

Poster Details

First Author: M.Henriquez PERU

Co Author(s):    M. Rincon   J. Mejias   L. Izquierdo              

Abstract Details


To evaluate visual, refractive, and tomographic changes in progressive and no progressive keratoconus at 3 months follow-up and to determinate risk factors associated to progression.


Research Department, Oftalmosalud Instituto de Ojos, Lima, Peru.


This prospective cohort study included 106 eyes with new keratoconus diagnosis between July 2012 and January 2017. Scheimpflug imaging analysis, visual acuity and refraction at the time of diagnosis and 3 months after was performed. Progression was defined as an increase in the steeper keratometry (Kmax) of 1.0 Diopter (D) at 3 months of follow-up. Wilcoxon test as non-parametric and T-student test as parametric alternative were used, risk ratio, and odds ratio were calculated to detect risk factors associated to progression.


14 eyes (13.20%) experienced progression at 3 months of follow-up. Mean change in Kmax in the progressive group and no progressive group was �.34D and -0.32 respectively (p<. 001), mean change in astigmatism in progressive and no progressive group was 1.00D y �.11D respectively (p=0.03). Mean change in the Index of surface variance (ISV) was �.28 �Î�¼m in the progressive and -0.41�Î�¼m (p<. 001) in the no progressive. An increase of 7 �Î�¼m in ISV at 3 months showed an AUROC of 0.97, (RR= 16.42, p<. 001) and an increase in astigmatism > 0.7D had a RR=7.5 (p=0.001).


Progression can be assessed at short-term follow up. Index of surface variance and astigmatism are predictive factors for progression.

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