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Assessment of corneal endothelial changes in pseudoexfoliation patients using specular microscopy

Poster Details

First Author: S.Ganatra INDIA

Co Author(s):    M. Patel                    

Abstract Details


To evaluate changes in the corneal endothelial morphology in patients with pseudo exfoliation (PEX) syndrome.


M and J Western Regional Institute of Ophthalmology, Ahmedabad, Gujarat, India


Study included 220 eyes in a tertiary referral care center. In this group of patients there were 110 eyes with PEX syndrome and 110 eyes normal without PEX syndrome. Endothelial cell density, Corneal thickness and Hexagonality of cells were measured in each eye by specular microscopy and were compared between two groups.


The endothelial cell density in eyes with pseudo exfoliation was 2212.60 �Â�± 312.34 cells/mm2 & in controls 2588.06 �Â�± 286.54cells/mm2. The average cell size of cases was 492.40 �Â�± 72.12 �Î�¼m2 and of controls was 426.44 �Â�± 73.40 �Î�¼m2 (p<0.05). Hexagonality of corneal cells in the cases varied from 11 % to 90 % with a mean of 48.35 %. The controls had a mean of 62.02 % (p<0.05). There was a statistical difference in the cell density, cell size and hexagonality of the two groups.


Our study showed that in Pseudo exfoliation syndrome, endothelial cell density and the percentage of hexagonal cells are reduced. However average cell size was increased. Therefore, ophthalmologists must be careful in conducting cataract surgery, use of high viscosity viscoelastics.

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