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Herpes simplex virus endothelial keratitis treatment: our protocol

Poster Details

First Author: O.Evren Kemer TURKEY

Co Author(s):    E. Karaca   D. Ozek                 

Abstract Details


The presence of stromal and epithelial edema with inflammation at the level of corneal endothelium, signified by keratic precipitates in the absence of significant anteior uveitis, classified as herpetic simplex virus (HSV) endothelial keratitis responds rapidly to proper combination of antiviral and topical corticosteroid therapy. We aimed to evaluate the treatment of HSV endothelial keratitis in our clinic and give a simple protocol for regulating relative doses of antiviral and topical corticosteroid therapy.


Health Sciences University, Ankara Numune Education and Research Hospital, Department of Ophthalmology


Seventeen patient with HSV endothelial keratitis, underwent acyclovir and topical corticosteroid therapy. Oral acyclovir and topical dexamethasone were given to each patient. The symptoms and signs were evaluated before and after the therapy 1 st week, 2 nd week and then followed up every 2 weeks until recovery. The antiviral agent is reduced to prophylactic dose after 10-12 weeks and maintained as long as topical corticosteroids are in use. For each drop of topical corticosteroid, 200 or 400 mg of oral acyclovir was administered. We followed up recurrence every 3 months after recovery


Patients were followed up 7-48 months (mean 22.5 �Â�± 14.8 months). The cure time was 8-12 weeks. Among the oral acyclovir administered 15 patients; while 7 of the them (46%) was given 200 mg oral acyclovir for per drop of corticosteroid, 8 patients (54%) took 400 mg oral acyclovir for per drop. 6 of the patients (35%) had herpetic attack during the treatment. Among these six patients; four of them (67%) was under prophylaxis and two of them (33%) was under treatment. There was no recurrence rate in patients taking 400 mg oral acyclovir for each drop of corticosteroid.


400 mg of acyclovir for each drop of topical corticosteroid could cure and reduce recurrent rate of HSV endothelial keratitis effectively

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