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Iridocorneal endothelial syndrome: case report of Chandler's variant

Poster Details

First Author: D.Chianello BRAZIL

Co Author(s):    C. Estacia   A. Gameiro   P. Faccenda   M. Alves           

Abstract Details


To report a rare case of Chandler's Syndrome and its findings to help in proper and early diagnosis and management


HFSE (Hospital Federal dos Servidores do Estado), Rio de Janeiro, Brazil


We report in this study a case of Chandler's Syndrome, in a 56 years old female patient complaining about low vision in the right side, as well as itching and photophobia. In the first evaluation, visual acuity of the right eye was counting fingers at 0,5 meters, and we observed corneal swelling with microcystus and conjunctival hyperemia. The left eye was normal. We noticed in corneal specular microscopy the presence of ice cells. In current biomicroscopy it is remarkable the corneal swelling, with central opacity and the lens is not visible, as well as the fundoscopy is impossible


Chandler's Syndrome is a rare disease, characterized by abnormalities at corneal endothelium, obstruction of iriodocorneal angle and iris abnormalities, such as atrophy. It is considered as a variant of Iridocorneal Endothelium Syndrome. The other two variants are: essential iris atrophy and Coogan-Reese Syndrome. Chandler's syndrome usually affects women, between the ages of 30 and 50 years old, and customarily there is no familiar history. Normally the accometiment is unilateral. The objective of the treatment is to prevent the increase of intraocular pressure (IOP) and corneal swelling, that can lead to variable loss of visual acuity


We report a patient with clinical features compatible with Chandler's syndrome: endothelial abnormalities, difuse corneal edema, glaucoma and changes in pupil shape. Patients with this syndrome should be frequently followed by ophthalmologists, because the disease is chronic and progressive. Early features can be observed in specular microscopy when just a small portion of angles of anterior chamber has synechias, and even before glaucoma develops. More studies are necessary to describe the incidence of this disease, as well as to confirm its etiology. The best way to treat is still under discussion, and the prognosis is still reserved nowadays.

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