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The effects of nepafenac ophthalmic suspension 0.1% and bromfenac sodium ophthalmic solution 0.1% on tear film and ocular surface after cataract surgery

Poster Details

First Author: Y.Monden JAPAN

Co Author(s):    F. Hotokezaka   Y. Matsuo   S. Maeda   M. Kasaoka   R. Yamashita   R. Yamakawa     

Abstract Details

Purpose:

To evaluate the effects of nepafenac ophthalmic suspension 0.1% and bromfenac sodium ophthalmic solution 0.1% on tear film and ocular surface after cataract surgery.

Setting:

Department of Ophthalmology, Kurume University Hospital.

Methods:

This prospective study comprised 56 eyes of 46 patients who underwent phacoemulsification. Patients with dry eye and/or diabetes were excluded from the study. Patients were randomly assigned to receive nepafenac (nepafenac group) or bromfenac (bromfenac group) after cataract surgery. Corneal and conjunctival fluorescein and lissamine green staining, tear breakup time (BUT), noninvasive BUT measured with the Oculus keratograph 5M (NIBUT), Schirmer test, corneal sensitivity test, conjunctival impression cytology, and subjective dry eye symptom assessment were performed before and 1 day, 1 week, 1 month, and 2 months after the surgery.

Results:

Fluorescein staining score in bromfenac group was significantly higher at 1 week postoperatively than nepafenac group. Mean goblet cell density in bromfenac group significantly decreased at 1 month postoperatively compared with nepafenac group. Dry eye symptom and ocular irritation in bromfenac group significantly increased at 2 months postoperatively compared with nepafenac group.

Conclusions:

Nepafenac ophthalmic suspension 0.1% is less likely to cause damage to ocular surface after cataract surgery.

Financial Disclosure:

NONE

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