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Corneal structure and endothelial morphological changes after uneventful phacoemulsification in type 2 diabetic and non-diabetic patients

Poster Details

First Author: G.Godinho PORTUGAL

Co Author(s):    J. Beato   J. Esteves-Leandro   D. Reis   M. Falcao   A. Carneiro   F. Falcao-Reis     

Abstract Details

Purpose:

To compare corneal structure and endothelial morpohological changes after uneventful phacoemulsification cataract surgery between non-diabetic and type 2 diabetic patients (DM), and determine which factors may predict greater endothelial cell density (ECD) loss.

Setting:

Department of Ophthalmology, Centro Hospitalar S�Ã�£o Jo�Ã�£o, Porto, Portugal

Methods:

Forty-five diabetic (45 eyes) and 43 (43 eyes) age and sex-matched non-DM controls with age-related cataract were enrolled in this prospective observational study. Corneal (tickness and volume) and anterior segment (AS) parameters were measured by sheimpflug tomography, and ECD and morphology (coefficient of variation of cell size, hexagonal cells) were recorded using non-contact specular microscopy at baseline and at 1 and 6 months postoperatively. Uni and multivariate linear regression analyses were performed to evaluate the relationship between the demographical, clinical, ocular, intraoperative parameters and postoperative ECD changes at 6 months.

Results:

There was a significant postoperative ECD reduction 6 months after surgery (p<0.001) by an average of 378�Â�±388 cels (16%) and 501�Â�±368 mmHg (21%) in the DM group and non-DM groups, respectively (p=0.130). The mean postoperative central corneal thickness at 1 and 6 months did not change significantly from the mean preoperative level in both groups (p>0.05). Multivariate linear regression analysis showed that older age (p=0.042) and higher cataract grade (p=0.001) were significantly associated with greater absolute and relative ECD reduction at 6 months follow-up.

Conclusions:

This study showed that older age and denser cataracts may predispose to greater ECD reduction after cataract surgery. Other factors, such as DM and preoperative AS parameters, did not influence the ECD postoperative changes.

Financial Disclosure:

NONE

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