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Antihypertensive therapy effect on tear film osmolarity during early postoperative period after cataract surgery

Poster Details

First Author: E.Elksnis LATVIA

Co Author(s):    A. Balode   I. Priedniece   G. Laganovska              

Abstract Details


To evaluate the tear film osmolarity (TFO) of cataract patients with long-term anti hypertensive therapy (antiHT) record in medical history during first postoperative month.


Pauls Stradins Clinical University Hospital


This is case-controled, prospective study. Only patients with primary arterial hypertension and treated > 5 years with antiHT were included in the research group. The following conditions, which are stated as increasing TFO were excluded from the study: diabetes mellitus, pseudoexfoliation syndrome, contact lens wearers, any eye drop users. The control group was composed of patients with no arterial hypertension diagnosis. TearLab Osmolarity test of the operated eye was performed before cataract surgery and monitored next morning, one week and month after operation. The collected data were analyzed with Microsoft Office Excel 2010 and IBM SPSS Statistics 22.0 version.


In total 28 patients were enrolled in the reaserch and 37 in the control groups. Mean TFO before the operation in the study group 309.9 mOsm/L, in control group 301.2 mOsm/L. Next morning the TFO decreased in both groups <275 mOsm/L. The TFO one week after averaged 317.3 mOsm/L in the research and 311.8 mOsm/L in control group. Month after operation TFO in the research 310.6 and 303.2 mOsm/L in control groups. TFO changes during the postoperative period were significant in research (p<0,01) and control (p< 0,001) groups. The difference of TFO between groups was statistically significant (p<0.05).


This study proved statistically significant increase of TFO in both: research and control groups, during early postoperative period after cataract surgery. There were significant decrease below range of TFO next morning after operation and increased average numbers, crossing globally accepted threshold of physiologically healthy TFO, following one week after surgery. One month after operation the numbers of TFO approximated to the levels before the operation. The antiHT group TFO measurements were higher during the research monitoring period comparing with the control group, except next morning after surgery.

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