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Comparison of clinical outcomes between Dresden and accelerated corneal cross-linking in cases of progressive keratoconus

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Session Details

Session Title: Presented Poster Session: Cornea IV

Venue: Poster Village: Pod 3

First Author: : T.Kojima JAPAN

Co Author(s): :    M. Morikawa   Y. Yoshida   T. Nakamura   Y. Satoh   K. Ichikawa  

Abstract Details

Purpose:

To compare the clinical outcomes between the Dresden protocol and accelerated corneal crosslinking (CXL) in cases with progressive keratoconus.

Setting:

Nagoya Eye Clinic, Nagoya, Japan Satoh Yuya Eye Clinic, Sendai, Japan

Methods:

Sixty-seven eyes of 56 Japanese patients with progressive keratoconus who underwent corneal crosslinking and were followed-up for 1 year were enrolled in this retrospective comparative study. The Dresden protocol involved application of riboflavin, then ultraviolet (UV) light (3 mW/cm2) irradiation for 30 minutes. Accelerated crosslinking comprised UV irradiation (KLX system, Avedro; 18 mW/cm2) for 5 minutes. Uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), average keratometric power and cylinder (measured by TMS4, TOMEY), and postoperative complications were compared between the 2 groups. Friedman test was used for statistical analyses with p<0.05 indicating statistical significance.

Results:

The mean UDVA and CDVA in both groups significantly improved 1 year after surgery (UDVA: pDresden=0.007, pAccelerated CXL=0.023; CDVA: pDresden =0.027, pAccelerated CXL= 0.016). The mean average K in both groups significantly decreased 1 year after surgery (Dresden: from 48.5±4.5D to 47.5±4.3D, p=0.037; accelerated CXL: from 49.5±5.9D to 47.7±4.7D, p=0.022). Corneal refractive cylinder and corneal endothelial cell densities in both groups were not significantly different before and 1 year after surgery. At the 1-year follow-up visit, 5 eyes in the Dresden group and 1 eye in the accelerated CXL group showed faint deep stromal opacity.

Conclusions:

The study revealed that the Dresden protocol and accelerated CXL have equivalent treatment effects in patients with progressive keratoconus.

Financial Disclosure:

receives consulting fees, retainer, or contract payments from a company producing, developing or supplying the product or procedure presented

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