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A quantitative analysis of viral load in patients with adenovirus keratoconjunctivitis

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Session Details

Session Title: Moderated Poster Session: New and Interesting

Venue: Poster Village: Pod 1

First Author: : P.Isik TURKEY

Co Author(s): :    N. Kocu   E. Erdem   F. Yarkin   M. Yagmur   R. Ersoz  

Abstract Details

Purpose:

To investigate the relationship between the clinical severity and viral quantitative load detected by polymerase chain reaction (PCR) in adenoviral keratoconjunctivitis.

Setting:

Cukurova University Faculty of Medicine, Ophthalmology and Virology Departments

Methods:

Conjunctival swab samples were taken for real-time PCR analysis from patients with clinically suspected adenoviral conjunctivitis. Patients were divided into two groups as low positive (<100,000 copies) (Group 1) and high positive (> 1,000,000 copies) (Group 2) according to the number of DNA copies detected. The two groups were compared in terms of clinical features.

Results:

Twenty-nine eyes of 29 patients (17 female, 12 male), 8 in Group 1 and 21 in Group 2 were included in the study. The mean age was 36 16 ranged from 1 to 73 years. Clinical findings in Group 1 and 2 were; eyelid edema %75 and %90, chemosis %25 and %67, conjunctival hemorrhage 71% and 100%, conjunctival follicles 63% and 71%, pseudomembran 38% and 62%, punctate keratopathy 50% and 57%, corneal subepithelial deposit % 25 and 48% respectively.

Conclusions:

In this study, it was observed that the clinical presentation was more severe in cases with a high virus load. For these severe cases contagiousness may be more likely, so preventive measurements should be keep in mind.

Financial Disclosure:

NONE

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