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Effectiveness of a preservative-free eyedrop, Cyclosporine 0.05% emulsion, and Omega-3 supplement on dry eye

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Session Details

Session Title: Presented Poster Session: Quality of Vision/Miscellaneous

Venue: Poster Village: Pod 3

First Author: : A.Al-Awadi USA

Co Author(s): :    J. Caines   B. Wan   E. Tam   R. Maini   S. Somani  

Abstract Details


We aim to evaluate the impact of combining a preservative-free drop, cyclosporine 0.05% emulsion, and Omega-3 oral supplementation on the signs and symptoms of dry eye in a typical ophthalmic practice.


Uptown Eye Specialists. University of Toronto


Patients diagnosed with dry eye in a typical ophthalmology practice were initiated on a combination regimen which included PureGel (a preservative-free eye drop), cyclosporine 0.05% ophthalmic emulsion, and oral Omega-3 supplement for 3 months. The primary outcome measured was a symptom score using the Canadian Dry Eye Assessment tool (CDEA). Secondary outcome measure was Non-invasive Keratograph Break-up Time (NIKBUT). Primary and secondary outcomes measured at baseline and 3 months following intervention were compared.


Thirty-seven consecutive patients were included with a female:male ratio of 27:10 and average age of 64.32. Patient symptoms improved significantly following the intervention as shown by a lower CDEA score during the second visit compared to the first (p < .05). NIKBUT scores were also significantly improved in both the right (p < .05) and left (p < .01) eyes.


A combination of preservative-free eye drops, cyclosporine 0.05% and Omega-3 supplementation may be an effective treatment option in alleviating symptoms and improving signs of patients suffering from dry eye.

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