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Serum selenium concentration is associated with the development of age-related cataract

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Session Details

Session Title: Presented Poster Session: Quality of Vision/Miscellaneous

Venue: Poster Village: Pod 3

First Author: : M.Post POLAND

Co Author(s): :    K. Krzystolik   W. Lubinski   J. Lubinski   M. Lener   M. Muszynska   M. Lener

Abstract Details

Purpose:

1) Assessment of the serum selenium concentration of patients age-related cataract surgery and reference of the results to the control group, 2) Assessment of the single nucleotide polymorphisms of glutathione peroxidase 1 and 4 (GPX-1 and GPX-4) of patients age-related cataract surgery and reference of the results to the control group, 3) To evaluate the correlation between the occurrence of age-related cataract, serum selenium concentration and single nucleotide polymorphisms of GPX-1 and GPX-4 genes.

Setting:

1) Department of Ophthalmology, Pomeranian Medical University, Szczecin, Poland 2) Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland

Methods:

A study group was 95 age-related cataract patients (36 men, 59 women), who underwent cataract surgery. The control group was 181 (68 men, 113 women). The mean age was 70.9 years ± 7.36 (age range: 53-88 years). Matching criteria for the control group were: sex, age, smoking, number of pack-years smoked. All participants (94 operated and 181 not operated) were evaluated with LOCS III. Risk factors for age-related cataract were analyzed with multivariate logistic regression. Single nucleotide polymorphisms of GPX-1 (Rs1050450) and GPX-4 (Rs713041) was analyzed with Real Time PCR. Selenium levels in serum were determined with ICPMS

Results:

The low concentration of selenium significantly increased the risk of occurrence of age-related cataract (OR 7.969, 95% CI: 3,391-20,672, p <0.01), nuclear cataract (OR 12.823, 95% CI 5,672-30,972 p <0.01) and cortical cataract (OR 3.31, 95% CI 1,635-6,866, p <0.01). Factors such as gender, age, single nucleotide polymorphisms of GPX-1/GPX-4 had no significant effect on the age-related cataract occurrence. No significant differences in LOCS III between the genders were found. Serum selenium level 75-85 µg/l corresponded with the lowest occurrence of age-related cataract.

Conclusions:

1) Patients with clinically significant age-related cataract surgery had lower serum selenium concentration in comparison to control group, 2) No significant differences in single nucleotide polymorphisms of GPX-1 and GPX-4 genes between patients with clinically significant age-related cataract surgery and control group were found, 3) Serum selenium concentration correlates with the occurrence of age-related cataracts. The low selenium levels may be a risk factor for age-related cataract, 4) Single nucleotide polymorphisms of GPX-1 and GPX-4 genes do not correlate with the occurrence of age-related cataract

Financial Disclosure:

NONE

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