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Clinical features and visual function in fish-eye disease

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Session Details

Session Title: Presented Poster Session: Quality of Vision/Miscellaneous

Venue: Poster Village: Pod 3

First Author: : M.Kanai JAPAN

Co Author(s): :    S. Koh   D. Masuda   M. Koseki   K. Nishida     

Abstract Details


Bilateral corneal opacity is a hallmark of the clinical manifestation of fish-eye disease. The dense corneal opacification is slowly progressive and causes severe visual impairment. Fish-eye disease is also known as partial lecithin-cholesterol acyltransferase deficiency. To investigate the clinical features and visual function in fish-eye disease by quantitative measurement of visual function and anterior segment optical coherence tomography (OCT).


Osaka University Hospital, Osaka, Japan


This is a case report.


A 36-year-old Japanese woman with fish-eye disease presented with bilateral corneal opacity and visual complaints including hazy vision, photophobia, and visual impairment in darkness. Both contrast sensitivity and straylight were measured, which showed remarkably decreased visual function, despite good visual acuity. OCT demonstrated homogenously hyperreflective corneal opacification and provided corneal thickness. Total corneal thickness appeared to be normal (513 µm for the right eye and 514 µm for the left eye), while corneal epithelial thickness was increased (57 µm for the right eye and 59 µm for the left eye).


OCT can reveal the clinical features of fish-eye disease. Quantitative measurement of visual function aids in understanding the vision-related symptoms of fish-eye disease, regardless of good standard visual acuity.

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