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The clinical characteristics of ocular toxocariasis in Jeju, an isolated island in Korea using ultra-widefield fundus photography

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Session Details

Session Title: Presented Poster Session: Miscellaneous and Infections

Venue: Poster Village: Pod 3

First Author: : E.Lee SOUTH KOREA

Co Author(s): :    J. Lee   S. Lee           

Abstract Details

Purpose:

To investigate the clinical features and treatment outcomes of ocular toxocariasis using ultra-wide-field fundus photography in Jeju Island, Korea.

Setting:

Jeju National University Hospital, Jeju, South Korea

Methods:

We retrospectively reviewed the medical records of 40 eyes of 37 patients who diagnosed with ocular toxocariasis based on clinical aspects and serologic tests. History taking was performed to identify possible infection sources. Toxocara canis IgG titers and eosinophil counts were measured using peripheral blood samples. Ocular characteristics were evaluated using ultra-wide-field fundus photography and optical coherence tomography. Changes in visual acuity and funduscopic findings following treatment were also analyzed.

Results:

The average age of patients was 57.9 years and the mean Toxocara canis IgG titer was 1.979±0.486. The most common fundus findings were vitreous opacity(63.6%) and granuloma(60%). The granuloma that was not observed within the field of conventional fundus photography was found using ultra-wide-field imaging in 15 eyes(62.5%). Ultra-wide-field fluorescein angiography showed peripheral vascular leakage in 16 eyes(69.6%). Treatment with prednisolone and albendazole resulted in the average vision improvements of 0.19±0.07 logMAR (p=0.031), significant improvements in anterior chamber inflammation (p=0.017) and vitreous opacity (p=0.002). The combination therapy leads to a significantly lower recurrence rate than prednisolone monotherapy (p=0.049).

Conclusions:

In Jeju Island, the mean titer of serum Toxocara canis IgG of ocular toxocariasis was high. The incidence of vitreous opacity as well as granuloma was high. Ultra-wide-field fundus imaging was valuable not only in clinical diagnosis but also in follow-up evaluation of ocular toxocariasis. Treatment with oral prednisolone and albendazole was effective in improving the ocular inflammation and visual acuity and reducing the recurrence rate.

Financial Disclosure:

NONE

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