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Differences of the tear cytokines between atopic keratoconjunctivitis and chronic Stevens-Johnson syndrome

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Session Details

Session Title: Presented Poster Session: Miscellaneous and Infections

Venue: Poster Village: Pod 3

First Author: : M.Ueta JAPAN

Co Author(s): :    H. Nishigaki   C. Sotozono   S. Kinoshita        

Abstract Details

Purpose:

There are several ocular surface inflammatory disorders, for example, atopic keratoconjunctivitis and Stevens-Johnson syndrome. However, the differences in the pathophysiology of these ocular surface inflammations are not well known. To investigate the differences in the pathophysiology of atopic keratoconjunctivitis and chronic Stevens-Johnson syndrome, we compared the various cytokines in the tear of them.

Setting:

Department of Frontier Medical Science and Technology for Ophthalmology, Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan

Methods:

Tear samples from atopic keratoconjunctivitis and chronic Stevens-Johnson syndrome were collected on Schirmer’s measurement strips. To measure various cytokine levels in the tears, we used BD CBA Flex sets.

Results:

Among various cytokines such as IL-6, IL-8, MCP-1, IFN-, IP-10, MIP-1, Eotaxin, RANTES, and total IgE we examined, IP-10 was significantly downregulated in chronic Stevens-Johnson syndrome than atopic keratoconjunctivitis, and total IgE was significantly upregulated in atopic keratoconjunctivitis than chronic Stevens-Johnson syndrome, and IL-6, IL-8, MCP-1, IFN-, MIP-1, Eotaxin, and RANTES did not show significant differences between them.

Conclusions:

IP-10 downregulation in the tear of chronic Stevens-Johnson syndrome and total IgE upregulation in the tear of atopic keratoconjunctivitis might contribute to the differences in the pathophysiology of them.

Financial Disclosure:

NONE

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