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Retinal nerve fiber layer and ganglion cell complex thickness in multiple sclerosis

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Session Details

Session Title: Presented Poster Session: Miscellaneous and Infections

Venue: Poster Village: Pod 3

First Author: : K.Krix-Jachym POLAND

Co Author(s): :    I. Skrzypiec   I. Jamiolkowska   J. Wierzbowska   M. Rekas     

Abstract Details

Purpose:

The purpose of this study was to report anatomical changes of the retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) in patients with multiple sclerosis (MS).

Setting:

Military Institute of Medicine in Warsaw, Poland

Methods:

This retrospective study included 73 eyes of 44 patients. The patients were divided into two groups: group A included 34 eyes of 24 patients with diagnosis of MS; group B involved 39 eyes of 20 healthy patients. The examination included BCVA, Goldmann tonometry, biomicroscopic examination of the anterior segment and fundus of the eye, circumpapillary RNFL thickness and GCC.

Results:

MS group showed a significantly reduced cpRNFL and GCC thickness compared with the control group (P< 0.001). This reduction was more representative in patients with MS complicated by optic neuritis (ON). There was a strong correlation between GCC thickness and RNFL thickness in patients with MS (r 2 = 0.94).

Conclusions:

The significant statistical evidence of cpRNFL and GCC thinning support the use of OCT in the evaluation, treatment, and follow-up of patients diagnosed with MS. Optical coherence tomography (OCT) is useful to assess the degree of nerodegeneration in patients with MS.

Financial Disclosure:

NONE

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