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Retinal nerve fiber layer and ganglion cell complex thickness in multiple sclerosis

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Session Details

Session Title: Presented Poster Session: Miscellaneous and Infections

Venue: Poster Village: Pod 3

First Author: : K.Krix-Jachym POLAND

Co Author(s): :    I. Skrzypiec   I. Jamiolkowska   J. Wierzbowska   M. Rekas     

Abstract Details


The purpose of this study was to report anatomical changes of the retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) in patients with multiple sclerosis (MS).


Military Institute of Medicine in Warsaw, Poland


This retrospective study included 73 eyes of 44 patients. The patients were divided into two groups: group A included 34 eyes of 24 patients with diagnosis of MS; group B involved 39 eyes of 20 healthy patients. The examination included BCVA, Goldmann tonometry, biomicroscopic examination of the anterior segment and fundus of the eye, circumpapillary RNFL thickness and GCC.


MS group showed a significantly reduced cpRNFL and GCC thickness compared with the control group (P< 0.001). This reduction was more representative in patients with MS complicated by optic neuritis (ON). There was a strong correlation between GCC thickness and RNFL thickness in patients with MS (r 2 = 0.94).


The significant statistical evidence of cpRNFL and GCC thinning support the use of OCT in the evaluation, treatment, and follow-up of patients diagnosed with MS. Optical coherence tomography (OCT) is useful to assess the degree of nerodegeneration in patients with MS.

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