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How reliable are spectral domain optical coherence tomography glaucoma software and normative databases in the early diagnosis of glaucoma?

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Session Details

Session Title: Presented Poster Session: Glaucoma

Venue: Poster Village: Pod 2

First Author: : N.Solmaz TURKEY

Co Author(s): :    M. Ustaoglu   F. Onder           

Abstract Details

Purpose:

To investigate the reliability of spectral domain optical coherence tomography (SD-OCT) glaucoma software and normative databases for retinal nerve fibre layer (RNFL) thickness in the early diagnosis of glaucoma.

Setting:

University of Health Sciences, Haseki Training and Research Hospital, Ophthalmology Department, Istanbul, Turkey

Methods:

Sixty eyes, 30 with suspected glaucoma (Group I) and 30 with early glaucoma (Group II), were included in the study. All patients underwent RNFL imaging with Copernicus SD-OCT (Optopol Technology Sp.) and Cirrus HD-OCT (Carl Zeiss Meditec Inc.) on the same day. Firstly, the groups were separately compared with the RNFL data of the two devices to assess the discriminatory power of the OCT devices. Secondly, the color-coded graphical formats of RNFL data, on the basis of the age-related normative databases, were compared with each other; and, the agreement between the two OCT devices was investigated using the Kappa test.

Results:

The average and quadrant RNFL thickness parameters of the Copernicus SD-OCT were statistically different from each other for Group I and Group II (p<0.05). Except the average, there were not any statistically significant differences between the RNFL parameters of the Cirrus HD-OCT. The color-coded graphics of the Copernicus SD-OCT and the Cirrus HD-OCT were very significantly different from each other (p<0.001). The Cirrus HD-OCT yielded more optimal data on the superior and inferior quadrants in approximately 45% of the cases. The agreement between the two OCT devices on the diagnosis of the RNFL defects was fair (κ: 0.14-0.34).

Conclusions:

The OCT devices not only yield different results on the numerical values but differences also exist in the software, and in the analytical and interpretative assessments related to the normative database. We have observed the RNFL parameters obtained with the Cirrus HD-OCT to be less successful in comparison to those obtained with the Copernicus SD-OCT for the early diagnosis of glaucoma.

Financial Disclosure:

NONE

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