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Different reasons or a startup factor of hydrophilic IOL calcification?

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Session Details

Session Title: Presented Poster Session: Cataract Complications Management

Venue: Poster Village: Pod 1

First Author: : P.Gartaganis GREECE

Co Author(s): :    S. Alimisi   S. Gartaganis   P. Koutsoukos        

Abstract Details

Purpose:

To investigate the underlying physico-chemical processes and the nature of characteristic deposits causing late opacification of hydrophilic intraocular lenses (IOLs) based on the examination of clinical findings using scanning electron microscopy (SEM) and energy dispersive x-ray spectroscopy (EDX) analysis.

Setting:

1. From the Department of Ophthalmology and 2. the Department of Chemical Engineering, Laboratory of Inorganic and Analytical Chemistry, University of Patras and FORTH-ICEHT, Greece

Methods:

In an earlier publication, we described a number of calcified IOLs seen with some hydrophilic lenses as: Hydroview (Bausch & Lomb), MemoryLens (Ciba Vision), SC60B-OUV (Medical Developmental Research), and Aqua-Sense (Ophthalmic Innovations International). Also, in another study we investigated the characterization and the kinetics of development of calcified deposits on hydrophilic IOLs with construction of an experimental model simulating the environment of IOLs into the eye. Recently, six explanted calcified hydrophilic acrylic lenses with a hydrophobic surface were studied.

Results:

Examination of opacified IOLs showed a surface texture characterized of lumps containing salts, formed more likely in the interior of the IOLs. The morphology of crystalline deposits and the molar calcium: phosphorus corresponded to hydroxyapatite (Ca5. (PO4)3OH, HAP).Thermostated reactors simulating the anterior chamber’s conditions and simulated aqueous humor, were used for IOL opacification experiments in vitro. Analysis of hydrophilic IOLs with hydrophobic surface confirmed that the initiation of the calcification process was influenced by factors other than supersaturation conditions, such as the hydrophilic or hydrophobic nature of the IOLs. Explanted hydrophilic IOLs with a hydrophobic surface confirmed experimental analysis.

Conclusions:

The studies presented is a contribution to a better understanding of the pathogenetic mechanism, leading to hydrophilic acrylic IOL calcification, highlighting the significance of surface hydroxyl groups of the polyacrylic materials as a major factor that facilitate surface nucleation and growth.

Financial Disclosure:

NONE

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