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lamina cribrosa (LC) and choroid is thinning in Alzheimer’s disease patients: enhanced depth imaging optical coherence tomography study

Poster Details

First Author: M.Eraslan TURKEY

Co Author(s):    S. Yildiz Balci   E. Cerman   O. Sahin   O. Cekic   D. Suer   E. Tuncer Elmaci

Abstract Details

Purpose:

Comparing lamina cribrosa (LC) and choroidal thickness using enhanced depth imaging optical coherence tomography (EDI-OCT) in Alzheimer’s disease patients(AH) and healthy subjects.

Setting:

Marmara University School of medicine Department of Ophthalmology

Methods:

Twenty eight eyes of 14 AH patients and 54 eyes of 27 healthy subjects was enrolled to the study. After a complete ophthalmic examination, all study eyes were imaged with OCT (RTVue-100 5.1 Fourier-Domain Optical Coherence Tomography-Optovue Inc., Fremont, CA). Severity was evaluated with Mini Mental State Examination test

Results:

The groups were matched regarding age, gender, refractive errors, intraocular pressure, axial length and central corneal thickness.The mean LC thicknesses were 207.8±29.4 µm in AD and 295.7±32.4 µm in control subjects.There was a significant difference between groups regarding mean LC thickness.(P <.0001)The choroidal thickness of AD group at subfovea, 1.5 mm temporal and 1.5 mm nasal to the subfovea was 218.9±26.9 µm, 186.2±19.8 µm and 176.1±27.4 µm, respectively. Whereas it was 253.6±41.2, 234.8±33.7, 217.0±43.7 in controls. There was a significant difference between groups regarding mean choroidal thickness. (P <.0001)

Conclusions:

AD affect ophthalmic structures causing thinning in lamina cribrosa and choroid. Enhanced depth imaging technique may be used as an additional modality in diagnosis and follow-up of patients with AD. Imaging these changes with OCT may help in diagnosis and management.

Financial Disclosure:

NONE

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