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Is remaining drug effective on diabetic macular edema after breach and storage of a single-use vial of bevacizumab?

Poster Details

First Author: M.Demir TURKEY

Co Author(s):    D. Guven   Z. Acar   D. Ozcan   Y. Sendul   A. Demir  

Abstract Details

Purpose:

To investigate the effect of bevacizumab remaining after withdrawal of the first dose from a single-use vial in macular edema (ME) secondary to diabetic retinopathy (DR).

Setting:

Sisli Hamidiye Etfal Training and Research Hospital, Department of Ophthalmology

Methods:

Patients were divided into 4 groups according to duration of storage of the single-use vial of bevacizumab in the refrigerator: Group 1 received IVB when the vial was first opened, and groups 2, 3, and 4 received IVB after 3, 7, and 15 days, respectively, after the first dose or doses had been withdrawn with an insulin (27-gauge) needle from the single-use vial. The Wilcoxon test was used to compare visual acuity (VA) and central macular thickness (CMT) scores before and after treatment.

Results:

The mean VA increased significantly and CMT decreased significantly after injection in all groups. No observed serious ophthalmologic or sytemic side effects.

Conclusions:

Remaining bevacizumab appeared to be effective for ME secondary to DR. This may be useful for poor countries.

Financial Disclosure:

NONE

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