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Normal corneal endothelial morphology of healthy Saudi children aged 7–12 years

Poster Details

First Author: H.Alfarhan SAUDI ARABIA

Co Author(s):    W. Albalawai   W. Masoud           

Abstract Details

Purpose:

The aim of this study was to describe the corneal endothelial morphology of healthy Saudi children aged 7-12 years and investigate variations on the basis of age and sex.

Setting:

The endothelial cells morphology were determined by a noncontact Nidek CEM 530 specular microscope. An unpaired t-test was used to compare ECD measurements between boys and girls. The right eyes of the children were analyzed for the entire sample using Kruskal-Wallis and Spearman's correlation tests.

Methods:

412 children were selected randomly from a school population in Riyadh, Saudi Arabia. Comprehensive anterior segment examinations of all children were performed using a slit-lamp biomicroscope. Exclusion criteria were the use of contact lenses, dry eye, ocular surgery or abnormalities, hereditary corneal disorder, increased intraocular pressure, uveitis, and diabetes mellitus. Spherical and cylindrical refractions and intraocular pressure were determined by autorefractometry. All measurements of ECD, CV, and Hex were performed using the noncontact Nidek CEM 530. Informed consent was obtained from parents. The study was carried out in conformance with the ethical considerations in the 2008 Declaration of Helsinki.

Results:

The Kruskal-Wallis test showed statistically significant differences in ECD on the basis of age (P = 0.01) and Spearman's correlation test detected a weak negative correlation between ECD and age (−0.20, P = 0.0001). Analysis of the CV did not indicate any statistically significant differences with age (P = 0.98), but a weak positive correlation was detected between CV and age (r = 0.02, P = 0.69). No significant differences in Hex were observed at each age (P = 0.10), but a weak negative correlation was detected between Hex and age (r = −0.14, P = 0.001).

Conclusions:

In children, ECD decreases with increasing age whereas CV and Hex do not change significantly with age.

Financial Disclosure:

NONE

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