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Herpes Simplex Virus Type 1 Keratoconjunctivitis in a Neonate

Poster Details

First Author: M.Ustaoglu TURKEY

Co Author(s):    N. Solmaz   F. Onder           

Abstract Details

Purpose:

To report a case of Herpes Simplex Virus(HSV) type 1 keratoconjunctivitis in a neonate who was improved completely with topical ganciclovir therapy.

Setting:

Department of Ophthalmology, Haseki Training and Research Hospital, Istanbul/Turkey

Methods:

A three-weeks old neonate presented with purulent discharge and conjunctival hyperemia that had been lasting since postpartum day 3 despite topical antibiotic treatment. In medical history, she was born with cesarean delivery and her mother denied any sexually transmitted disease(STD) or any genital lesions before pregnancy. Firstly corneal and conjunctival bacterial cultures were obtained and then empirical topical penicillin therapy were administered once per hour in case of Neisseria Gonorrhea keratoconjunctivitis Bacterial culture was reported as negative on day 5 of therapy and there was no improvement on corneal ulcer. Then PCR and blood test for herpes was performed after non-healing period. Two days later, PCR test was resulted as positive for HSV type 1 and negative for HSV type 2. As blood test result, HSV1 IgM was negative and IgG positive whereas HSV2 IgM and IgG negative for both patient and her mother. Then penicillin treatment was discontinued and topical ganciclovir was administered five times in a day with intravenous acyclovir for encephalitis prophylaxis. The next day the lesions started to regress and improved completely on day 7 of anti-viral therapy

Results:

The neonatal conjunctivitis is mostly related to bacterial agents such as gonorrhea, chlamydia … But if there is not any improvement despite proper antibacterial therapy, herpes virus infections should be considered, though mother doesn't have any medical risk for HSV 2.

Conclusions:

-

Financial Disclosure:

NONE

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